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1

Ceramide forms channels in mitochondrial outer membranes at physiologically relevant concentrations

Leah J. Siskind, Richard N. Kolesnick, Marco Colombini

Journal:

Year:

2006

Language:

english

File:

PDF, 165 KB

english, 2006

2

Neutral ceramidase mediates nonalcoholic steatohepatitis by regulating monounsaturated fatty acids and gut IgA + B cells

Gu, Xuemei, Sun, Rui, Chen, Liang, Chu, Shenghui, Doll, Mark A., Li, Xiaohong, Feng, Wenke, Siskind, Leah, McClain, Craig J., Deng, Zhongbin

Journal:

Year:

2020

File:

PDF, 61.70 MB

2020

3

Mitochondrial Ceramide and the Induction of Apoptosis

Leah J. Siskind

Journal:

Journal of Bioenergetics and Biomembranes

Year:

2005

Language:

english

File:

PDF, 377 KB

english, 2005

4

Sphingosine Forms Channels in Membranes That Differ Greatly from Those Formed by Ceramide

Leah J. Siskind, Sharon Fluss, Minh Bui, Marco Colombini

Journal:

Journal of Bioenergetics and Biomembranes

Year:

2005

Language:

english

File:

PDF, 143 KB

english, 2005

5

Ceramide channels: Influence of molecular structure on channel formation in membranes

Meenu N. Perera, Vidyaramanan Ganesan, Leah J. Siskind, Zdzislaw M. Szulc, Jacek Bielawski, Alicja Bielawska, Robert Bittman, Marco Colombini

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

2012

Language:

english

File:

PDF, 950 KB

english, 2012

6

Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis

Jerry E. Chipuk, Gavin P. McStay, Archana Bharti, Tomomi Kuwana, Christopher J. Clarke, Leah J. Siskind, Lina M. Obeid, Douglas R. Green

Journal:

Year:

2012

Language:

english

File:

PDF, 1.31 MB

english, 2012

7

Enlargement and Contracture of C2-Ceramide Channels

Siskind, Leah J., Davoody, Amirparviz, Lewin, Naomi, Marshall, Stephanie, Colombini, Marco

Journal:

Biophysical Journal

Year:

2003

Language:

english

File:

PDF, 292 KB

english, 2003

8

Lipid Channels: Positive and Negative Cooperativity and Regulation by Proteins

Ganesan, Vidyaramanan, Perera, Meenu N., Siskind, Leah, Szulc, Zdzislaw, Bielawska, Alicja, Colombini, Marco

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 37 KB

english, 2009

9

Bcl-2 Family Proteins Regulate the Ability of Ceramide Channels to Permeabilize the Mitochondrial Outer Membrane to Proteins

Colombini, Marco, Perera, Meenu N., Ganesan, Vidyaramanan, Siskind, Leah J.

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 86 KB

english, 2011

10

BAK activation is necessary and sufficient to drive ceramide synthase-dependent ceramide accumulation following inhibition of BCL2-like proteins

Beverly, Levi, Howell, Lauren, Hernandez-Corbacho, Maria, Casson, Lavona, Chipuk, Jerry, Siskind, Leah

Journal:

Biochemical Journal

Year:

2013

Language:

english

File:

PDF, 884 KB

english, 2013

11

Glucose Availability and Glycolytic Metabolism Dictate Glycosphingolipid Levels

Stathem, Morgan, Marimuthu, Subathra, O'Neal, Julie, Rathmell, Jeffrey C., Chesney, Jason A., Beverly, Levi J., Siskind, Leah J.

Journal:

Journal of Cellular Biochemistry

Year:

2015

Language:

english

File:

PDF, 552 KB

english, 2015

12

Sphingolipids and mitochondrial apoptosis

Patwardhan, Gauri A., Beverly, Levi J., Siskind, Leah J.

Journal:

Journal of Bioenergetics and Biomembranes

Year:

2016

Language:

english

File:

PDF, 772 KB

english, 2016

13

Ceramide channels: destabilization by Bcl-xL and role in apoptosis

Chang, Kai-Ti, Anishkin, Andriy, Patwardhan, Gauri A., Beverly, Levi J., Siskind, Leah J., Colombini, Marco

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

2015

Language:

english

File:

PDF, 1.76 MB

english, 2015

14

Kidney glycosphingolipids are elevated early in diabetic nephropathy and mediate hypertrophy of mesangial cells

Subathra, Marimuthu, Korrapati, Midhun, Howell, Lauren A., Arthur, John M., Shayman, James A, Schnellmann, Rick G., Siskind, Leah Jean

Journal:

AJP: Renal Physiology

Year:

2015

Language:

english

File:

PDF, 2.52 MB

english, 2015

15

Ceramide channel: Structural basis for selective membrane targeting

Perera, Meenu N., Ganesan, Vidyaramanan, Siskind, Leah J., Szulc, Zdzislaw M., Bielawska, Alicja, Bittman, Robert, Colombini, Marco

Journal:

Chemistry and Physics of Lipids

Year:

2015

Language:

english

File:

PDF, 889 KB

english, 2015

16

Repeated administration of low-dose cisplatin in mice induces fibrosis

Sharp, Cierra N., Doll, Mark A., Dupre, Tess V., Shah, Parag P., Subathra, Marimuthu, Siow, Deanna, Arteel, Gavin E., Megyesi, Judit, Beverly, Levi J., Siskind, Leah J.

Journal:

AJP: Renal Physiology

Year:

2016

Language:

english

File:

PDF, 2.15 MB

english, 2016

17

Bridging translation for acute kidney injury with better preclinical modeling of human disease

Skrypnyk, Nataliya I., Siskind, Leah J., Faubel, Sarah, de Caestecker, Mark P.

Journal:

AJP: Renal Physiology

Year:

2016

Language:

english

File:

PDF, 123 KB

english, 2016

18

Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins

Romero Rosales, Kimberly, Singh, Gurpreet, Wu, Kevin, Chen, Jie, Janes, Matthew R., Lilly, Michael B., Peralta, Eigen R., Siskind, Leah J., Bennett, Michael J., Fruman, David A., Edinger, Aimee L.

Journal:

Biochemical Journal

Year:

2011

Language:

english

File:

PDF, 1.54 MB

english, 2011

19

Developing Better Mouse Models to Study Cisplatin-Induced Kidney Injury

Sharp, Cierra N, Siskind, Leah J

Journal:

American journal of physiology. Renal physiology

Year:

2017

Language:

english

File:

PDF, 803 KB

english, 2017

20

Regulation of insulin-like growth factor receptors by ubiquilin1

Kurlawala, Zimple, Dunaway, Rain, Shah, Parag P, Gosney, Julie A., Siskind, Leah J, Ceresa, Brian P, Beverly, Levi J

Journal:

Biochemical Journal

Year:

2017

Language:

english

File:

PDF, 4.74 MB

english, 2017

21

Accumulation of Long-Chain Glycosphingolipids during Aging Is Prevented by Caloric Restriction

Hernández-Corbacho, María José, Jenkins, Russell W., Clarke, Christopher J., Hannun, Yusuf A., Obeid, Lina M., Snider, Ashley J., Siskind, Leah J., Riezman, Howard

Journal:

Year:

2011

Language:

english

File:

PDF, 1.67 MB

english, 2011

22

c-Abl Is an Upstream Regulator of Acid Sphingomyelinase in Apoptosis Induced by Inhibition of Integrins αvβ3 and αvβ5

Ren, Xiuhai, Xu, Jingying, Cooper, Jason P., Kang, Min H., Erdreich-Epstein, Anat, Siskind, Leah J.

Journal:

Year:

2012

Language:

english

File:

PDF, 921 KB

english, 2012

23

Imaging Mass Spectrometry Visualizes Ceramides and the Pathogenesis of Dorfman-Chanarin Syndrome Due to Ceramide Metabolic Abnormality in the Skin

Goto-Inoue, Naoko, Hayasaka, Takahiro, Zaima, Nobuhiro, Nakajima, Kimiko, Holleran, Walter M., Sano, Shigetoshi, Uchida, Yoshikazu, Setou, Mitsutoshi, Siskind, Leah J.

Journal:

Year:

2012

Language:

english

File:

PDF, 1.84 MB

english, 2012

24

Inhibition of Ceramide Metabolism Sensitizes Human Leukemia Cells to Inhibition of BCL2-Like Proteins

Casson, Lavona, Howell, Lauren, Mathews, Lesley A., Ferrer, Marc, Southall, Noel, Guha, Rajarshi, Keller, Jonathan M., Thomas, Craig, Siskind, Leah J., Beverly, Levi J., Starczynowski, Daniel T.

Journal:

Year:

2013

Language:

english

File:

PDF, 2.07 MB

english, 2013

25

Substrate Compositional Variation with Tissue/Region and Gba1 Mutations in Mouse Models–Implications for Gaucher Disease

Sun, Ying, Zhang, Wujuan, Xu, You-Hai, Quinn, Brian, Dasgupta, Nupur, Liou, Benjamin, Setchell, Kenneth D. R., Grabowski, Gregory A., Siskind, Leah J.

Journal:

Year:

2013

Language:

english

File:

PDF, 3.19 MB

english, 2013

26

Complexation of C6-Ceramide with Cholesteryl Phosphocholine – A Potent Solvent-Free Ceramide Delivery Formulation for Cells in Culture

Sukumaran, Pramod, Lönnfors, Max, Långvik, Otto, Pulli, Ilari, Törnquist, Kid, Slotte, J. Peter, Siskind, Leah J.

Journal:

Year:

2013

Language:

english

File:

PDF, 373 KB

english, 2013

27

Suramin: A Potential Therapy for Diabetic Nephropathy

Korrapati, Midhun C., Howell, Lauren H., Shaner, Brooke E., Megyesi, Judit K., Siskind, Leah J., Schnellmann, Rick G., Mohanraj, Rajesh

Journal:

Year:

2013

Language:

english

File:

PDF, 5.96 MB

english, 2013

28

C22:0- and C24:0-dihydroceramides Confer Mixed Cytotoxicity in T-Cell Acute Lymphoblastic Leukemia Cell Lines

Holliday Jr., Michael W., Cox, Stephen B., Kang, Min H., Maurer, Barry J., Siskind, Leah J

Journal:

Year:

2013

Language:

english

File:

PDF, 2.91 MB

english, 2013

29

Reducing FLI1 Levels in the MRL/lpr Lupus Mouse Model Impacts T Cell Function by Modulating Glycosphingolipid Metabolism

Richard, Erin Morris, Thiyagarajan, Thirumagal, Bunni, Marlene A., Basher, Fahmin, Roddy, Patrick O., Siskind, Leah J., Nietert, Paul J., Nowling, Tamara K., Tsokos, George C.

Journal:

Year:

2013

Language:

english

File:

PDF, 541 KB

english, 2013

30

Alternation in the Glycolipid Transfer Protein Expression Causes Changes in the Cellular Lipidome

Kjellberg, Matti A., Backman, Anders P. E., Ohvo-Rekilä, Henna, Mattjus, Peter, Siskind, Leah J.

Journal:

Year:

2014

Language:

english

File:

PDF, 1.64 MB

english, 2014

31

FTY720 Induces Apoptosis of M2 Subtype Acute Myeloid Leukemia Cells by Targeting Sphingolipid Metabolism and Increasing Endogenous Ceramide Levels

Chen, Limin, Luo, Liu-Fei, Lu, Junyan, Li, Lianchun, Liu, Yuan-Fang, Wang, Jiang, Liu, Hong, Song, Heng, Jiang, Hualiang, Chen, Sai-Juan, Luo, Cheng, Li, Keqin Kathy, Siskind, Leah J.

Journal:

Year:

2014

Language:

english

File:

PDF, 6.40 MB

english, 2014

32

Subclinical kidney injury induced by repeated cisplatin administration results in progressive chronic kidney disease

Sharp, Cierra N., Doll, Mark A., Megyesi, Judit, Oropilla, Gabrielle B., Beverly, Levi J., Siskind, Leah J.

Journal:

American journal of physiology. Renal physiology

Year:

2018

Language:

english

File:

PDF, 1.81 MB

english, 2018

33

Handbook of Cell Signaling || The Role of Ceramide in Cell Regulation

Siskind, Leah J.

Year:

2010

Language:

english

File:

PDF, 614 KB

english, 2010

34

Neuraminidase activity mediates IL-6 production by activated lupus-prone mesangial cells

Sundararaj, Kamala, Rodgers, Jessalyn I., Marimuthu, Subathra, Siskind, Leah J., Bruner, Evelyn, Nowling, Tamara K.

Journal:

American journal of physiology. Renal physiology

Year:

2018

Language:

english

File:

PDF, 1.38 MB

english, 2018

35

The role of sphingolipids is acute kidney injury

Dupre, Tess V., Siskind, Leah J.

Journal:

Advances in Biological Regulation

Year:

2018

Language:

english

File:

PDF, 357 KB

english, 2018

36

Moderate aging does not exacerbate cisplatin-induced kidney injury or fibrosis despite altered inflammatory cytokine expression and immune cell infiltration

Sharp, Cierra N, Doll, Mark, Dupre, Tess V, Beverly, Levi J, Siskind, Leah J

Journal:

American journal of physiology. Renal physiology

Year:

2018

Language:

english

File:

PDF, 1.19 MB

english, 2018

37

Loss of the Na+/H+ exchange regulatory factor 1 increases susceptibility to cisplatin-induced acute kidney injury

Bushau-Sprinkle, Adrienne, Barati, Michelle, Conklin, Caryl, Dupre, Tess, Gagnon, Kenneth B., Khundmiri, Syed Jalal, Clark, Barbara, Siskind, Leah, Doll, Mark A., Rane, Madhavi, Brier, Michael, Covent

Journal:

The American Journal of Pathology

Year:

2019

Language:

english

File:

PDF, 8.26 MB

english, 2019

38

In Memoriam: Lina M. Obeid (1957â2019)

Snider, Ashley J., Cowart, L. Ashley, Luberto, Chiara, Siskind, Leah J.

Journal:

The Journal of Lipid Research

Year:

2020

File:

PDF, 630 KB

2020

39

Ubiquilin proteins regulate EGFR levels and activity in lung adenocarcinoma cells

Kurlawala, Zimple, Saurabh, Kumar, Dunaway, Rain, Shah, Parag P., Siskind, Leah J., Beverly, Levi J.

Journal:

Journal of Cellular Biochemistry

Year:

2020

File:

PDF, 1.85 MB

2020

40

C57BL/6 mice require a higher dose of cisplatin to induce renal fibrosis and CCL2 correlates with cisplatin-induced kidney injury

Sears, Sophia M, Sharp, Cierra N, Krueger, Austin M, Oropilla, Gabrielle B, Saforo, Douglas, Doll, Mark A, Megyesi, Judit, Beverly, Levi J, Siskind, Leah J

Journal:

American journal of physiology. Renal physiology

Year:

2020

File:

PDF, 3.77 MB

2020

41

UBR-box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target

Saurabh, Kumar, Shah, Parag P., Doll, Mark A., Siskind, Leah J., Beverly, Levi J.

Journal:

Year:

2020

File:

PDF, 3.19 MB

2020

42

Novel heterozygous truncating titin variants affecting the Aâband are associated with cardiomyopathy and myopathy/muscular dystrophy

Rich, Kelly A., Moscarello, Tia, Siskind, Carly, Brock, Guy, Tan, Christopher A., Vatta, Matteo, Winder, Thomas L., Elsheikh, Bakri, Vicini, Leah, Tucker, Brianna, Palettas, Marilly, Hershberger, Ray

Journal:

Molecular Genetics & Genomic Medicine

Year:

2020

File:

PDF, 858 KB

2020